Menu
The world of science and progress
Pulsar Transformed Into Small Planet Made of Diamond Discovered in Milky Way

New Depiction of Light Could Boost Telecommunications Channels

Free Radicals Crucial to Suppressing Appetite

Preserving 4 Percent of the Ocean Could Protect Most Marine Mammal Species, Study Finds

Panda Poop May Be a Treasure Trove of Microbes for Making Biofuels

Discovery Sheds Light On the Ecosystem of Young Galaxies

New Method Reveals Parts of Bacterial Genome Essential to Life

Novel Alloy Could Produce Hydrogen Fuel from Sunlight

Tiny Oxygen Generators Boost Effectiveness of Anticancer Treatment

Bedrock Nitrogen May Help Forests Buffer Climate Change, Study Finds

'Gene Overdose' Causes Extreme Thinness

Manufacturing Method Paves Way for Commercially Viable Quantum Dot-Based LEDs

Cutting Soot Emissions: Fastest, Most Economical Way to Slow Global Warming?

Tasmanian Tiger's Jaw Was Too Small to Attack Sheep, Study Shows

Manipulating Plants' Circadian Clock May Make All-Season Crops Possible

NASA's Chandra Finds Nearest Pair of Supermassive Black Holes

Up from the Depths: How Bacteria Capture Carbon in the 'Twilight Zone'

Understanding Next-Generation Electronic Devices: Smallest Atomic Displacements Ever

Woolly Rhino Fossil Discovery in Tibet Provides Important Clues to Evolution of Ice Age Giants

Sparing or Sharing? Protecting Wild Species May Require Growing More Food On Less Land

Glowing, Blinking Bacteria Reveal How Cells Synchronize Biological Clocks

Rock Rafts Could Be 'Cradle of Life'

Robots Learn to Handle Objects, Understand New Places

World's Smallest Electric Motor Made from a Single Molecule

First Stem Cells from Endangered Species

Scientists Create Mammalian Cells With Single Chromosome Set
Researchers have created mammalian cells containing a single set of chromosomes for the first time in research funded by the Wellcome Trust and EMBO. The technique should allow scientists to better establish the relationships between genes and their function.

Mammal cells usually contain two sets of chromosomes -- one set inherited from the mother, one from the father. The genetic information contained in these chromosome sets helps determine how our bodies develop. Changes in this genetic code can lead to or increase the risk of developing disease.

To understand how our genes function, scientists manipulate the genes in animal models -- such as the fruit fly, zebrafish and mice -- and observe the effects of these changes. However, as each cell contains two copies of each chromosome, determining the link between a genetic change and its physical effect -- or 'phenotype' -- is immensely complex.

Now, in research published in the journal Nature, Drs Anton Wutz and Martin Leeb from the Wellcome Trust Centre for Stem Cell Research at the University of Cambridge report a technique which enables them to create stem cells containing just a single set of chromosomes from an unfertilised mouse egg cell. The stem cells can be used to identify mutations in genes that affect the cells' behaviour in culture. In an additional step, the cells can potentially be implanted into the mouse for studying the change in organs and tissues.

The technique has previously been used in zebrafish, but this is the first time it has been successfully used to generate such mammalian stem cells.

Dr Wutz, a Wellcome Trust Senior Research Fellowship, explains: "These embryonic stem cells are much simpler than normal embryonic mammalian stem cells. Any genetic change we introduce to the single set of chromosomes will have an easy-to-determine effect. This will be useful for exploring in a systematic way the signalling mechanisms within cell and how networks of genes regulate development."

The researchers hope that this technique will help advance mammalian genetics and our understanding of the gene-function relationship in the same way that a similar technique has helped geneticists understand the simpler zebrafish animal model.

Understanding how our genetic make-up functions and how this knowledge can be applied to improve our health is one of the key strategic challenges set out by the Wellcome Trust. Commenting on this new study, Dr Michael Dunn, Head of Molecular and Physiological Sciences at the Wellcome Trust, says:

"This technique will help scientists overcome some of the significant barriers that have so far made studying the functions of genes so difficult. This is often the first step towards understanding why mutations lead to disease and, ultimately, to developing new drugs treatments."

Для печати

Share USB over Network
mount s3 as drive

Menu
Growing Meat in the Lab: Scientists Initiate Action Plan to Advance Cultured Meat

Recycling Fat Might Help Worms Live Longer

In More Socially Engaging Environment, White Fat Turns to Brown, Mouse Study Suggests

Clouds Don't Cause Climate Change, Study Shows

Novel Magnetic, Superconducting Material Opens New Possibilities in Electronics

New Material Shows Promise for Trapping Pollutants

Breakthrough Could Double Wireless Capacity With No New Towers

Microbes Generate Electricity While Cleaning Up Nuclear Waste

Milky Way Galaxy Might Hold Thousands of Ticking 'Time Bombs'

Neurosurgeons Use Adult Stem Cells to Grow Neck Vertebrae

Jumping Gene's Preferred Targets May Influence Genome Evolution

Peer Pressure? It's Hardwired Into Our Brains, Study Finds

Scientists Create Mammalian Cells With Single Chromosome Set

Evidence for a Persistently Iron-Rich Ocean Changes Views On Earth's Early History

Nanosensors Made from DNA May Light Path to New Cancer Tests and Drugs

Endangered Horse Has Ancient Origins and High Genetic Diversity, New Study Finds

Australopithecus Sediba Paved the Way for Homo Species, New Studies Suggest

Babies Distinguish Pain from Touch at 35-37 Weeks, Research Finds

Mantis Shrimp: Ocean Floor Critters Communicate in Synchronized Rumbles

Powered by Seaweed: Polymer from Algae May Improve Battery Performance

Captivated by Critters: Humans Are Wired to Respond to Animals

Birth Control Pills Affect Memory, Researchers Find

NASA Launches Mission to Study Moon From Crust to Core

Sea Levels Much Less Stable Than Earlier Believed, New Coral Dating Method Suggests

Ferroelectrics Could Pave Way for Ultra-Low Power Computing